Basic Fibroblast Growth Factor

Report to Dr. Jones

15 July 2024

Basic fibroblast growth factor (bFGF) can be applied to the fallopian tubes as a therapeutic agent aimed at promoting tissue repair and regeneration. The application of bFGF involves several potential methods:

1. Direct Instillation: Similar to the G-CSF instillation procedure used in fertility treatments, bFGF can be directly instilled into the uterine cavity or the fallopian tubes through a thin catheter. This method ensures that the growth factor reaches the targeted area where it can stimulate cellular repair and regeneration processes[4].

2. Hydrotubation: This procedure involves flushing the fallopian tubes with a solution containing bFGF. Hydrotubation helps to clear blockages and can deliver the growth factor directly to the damaged areas, promoting healing and improving the chances of natural conception[2].

3. Microsurgical Techniques: During laparoscopic surgery, bFGF can be applied to the fallopian tubes to enhance the healing of tissues after surgical interventions aimed at removing obstructions or repairing damage. This targeted approach can improve surgical outcomes and tubal patency[5].

4. Endoscopic Application: Endoscopic procedures such as hysteroscopy or laparoscopy can be used to apply bFGF directly to the fallopian tubes. These minimally invasive techniques allow for precise delivery of the growth factor to the areas needing repair, thus promoting better recovery and function of the tubes[6].

These methods highlight the versatility of bFGF application in treating fallopian tuberelated infertility by leveraging its regenerative properties to improve tissue health and function.

🌐 Sources

1. mdpi.com – Application of Stem Cell Therapy for Infertility

2. ncbi.nlm.nih.gov – A systematic review and meta-analysis – PMC

3. varta.org.au – Study confirms ‘flushing’ blocked fallopian tubes can improve fertility

4. fertilitynorth.com.au – G-CSF Instillation Procedure (GIP)

5. webmd.com – What fallopian tube procedures help with fertility?

6. carefertility.com.au – Evaluation of the fallopian tubes